This medication is used to help relieve sudden (breakthrough) cancer pain in people who are regularly taking moderate to large amounts of opioid pain medication. Fentanyl belongs to a class of drugs known as opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain.
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Subsys Spray (Non-Aerosol) is used to help relieve sudden (breakthrough) cancer pain in people who are regularly taking moderate to large amounts of opioid pain medication. Fentanyl belongs to a class of drugs known as opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain. Subsys Spray (Non-Aerosol) should not be used to relieve mild or short-term pain (such as due to headache/migraine, dental procedures, surgery).
Read the Subsys Spray (Non-Aerosol) Guide and the Instructions For Use Leaflet provided by your pharmacistbefore you start using fentanyl and each time you get a refill. Learn all preparation, usage, and disposal instructions. If you have any questions, ask your doctor or pharmacist.
Open the blister package with scissors right before using this medication. Swallow any saliva in your mouth. Spray the medication in your mouth underneath the tongue. Hold the medication under your tongue for 30 to 60 seconds. Do not spit out the medication or rinse out your mouthafter using the spray.
Use Subsys Spray (Non-Aerosol) as directed by your doctor. If the pain is not relieved 30 minutes after using this medication, you may take another dose. Do not use more than 2 doses of this medication for each episode of breakthrough pain. Tell your doctor if you do not get pain relief within 30 minutes of using the second dose of this medication or if you have another episode of breakthrough pain within 4 hours of using this medication. You must wait at least 4 hours before using this medication again to treat another episode of breakthrough pain. Follow your doctor’s instructions on taking another medication to treat the pain before you can use this medication again.
The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor will direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully. Do not increase your dose or use this drug more often or for longer than prescribed.
Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.
You should continue to also take your long-acting opioid medication as directed by your doctor. Other pain relievers (such as acetaminophen, ibuprofen) may also be prescribed. Ask your doctor or pharmacist about using fentanyl safely with other drugs.
Suddenly stopping this medication may cause withdrawal, especially if you have used it for a long time or in high doses. To prevent withdrawal, your doctor may lower your dose slowly. Tell your doctor or pharmacist right away if you have any withdrawal symptoms such as restlessness, mental/mood changes (including anxiety, trouble sleeping, thoughts of suicide), watering eyes, runny nose, nausea, diarrhea, sweating, muscle aches, or sudden changes in behavior.
When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.
Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Use this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.
Tell your doctor if your pain does not get better or if it gets worse, or if you have more than 4 episodes of breakthrough pain daily, or if you need to use 2 doses of medication for each episode of pain.
200 mcg, 400 mcg, 600 mcg
5, 10, 30