JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2.
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$280.00 – $1,475.00
JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. JWH-018 produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as “incense blends”.
JWH-018 is a full agonist at both the CB1 and CB2 cannabinoid receptors, this chemical compound is classified as an analgesic medication. The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis.These compounds work by mimicking the body’s naturally-produced endocannabinoid hormones such as 2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signaling. As the cause is poorly understood in chronic pain states, more research and development must be done before we can realize the therapeutic potential of this class of biologic compounds.
JWH-018 Online Public health advisories:
The US Food and Drug Administration (FDA) has issued public health advisories related to JWH-018 Among these, in July 2005, the FDA issued a Public Health Advisory,which advised that “deaths and overdoses have occurred in patients using both the brand name and the generic JWH-018″ In December 2007, as part of this continuing investigation, the FDA issued a second Public Health Advisory stating, “The FDA has continued to receive reports of deaths and life-threatening side effects in patients who use this product patch. The reports indicate that doctors have inappropriately prescribed this product patch.In addition, the reports indicate that patients are continuing to incorrectly use this product patch.
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